Peyronie's disease is a progressive disease (fibromatosis) of the inner tunic of the penis. The therapeutic approach is the first doctor, then surgery. Goal of medical therapy is to stop the progression of the disease the surgery aims to improve the deformity of the penis induced fibromatosis and repair by grafting a prosthetic erectile dysfunction that may be surplus to medical therapy.

Peyronie's disease is a proliferative disease status (fibromatosis) of the inner tunic (albuginea) of the penis. The proliferative nature defines its evolution: in most cases (65% -87%) evolving nature, only a minority of cases tends to stabilize itself. The causes for these fibromatosis are unknown.

There are two stages of the disease: the first is acute, the second confirmed. Rarely, patients arrive in the acute phase; almost all arrive in chronic phase, not because of neglect of the first stage, but because the Peyronie’s disease symptoms are often scarce. The two phases are characterized by differences in the immune response ("rejection") organism against the plate.

Peyronie’s disease symptoms of the acute phase are: pain more or less pronounced and more or less localized, vague sensations to the penis, painful plaques.

The symptoms of chronic phase are apparently hard subcutaneous plaques, deformation of the penis, pain on erection, erectile dysfunction.

The diagnostic includes objective examination and Doppler Echo basal and dynamic of the penis. Contrary to popular belief, the echodoppler hand is less sensitive to determine the extent of surface plates, and used to identify possible infiltration of the corpora cavernosa and giving a clear picture of the vasculature, particularly important in case of presence of erectile dysfunction. In fact the symptom of erectile effect may be causes other than Peyronies, but be present in patients with Peyronie's, and this is particularly suspected.

First of all you need to go through treatment and then you might also need surgery. The goal of medical therapy is to stop the progression of the disease. If it improves to better, the improvement can not be included in the therapeutic contract, as the case of progressive disease, for which the stabilization is already a success. There are reports in the literature of healing, namely the total disappearance of the plate.

Residual deformity of the penis that affects the comfort of coitus indicates that surgery is needed. The surgery is chosen, between 100 and more interventions available, and if persistent erectile dysfunction resistant to medical therapy may be used to contextual insertion of implants.

Treatment includes substances for infiltration of the plaque (verapamil or interferon) and substances oral (tamoxifen, carnitine, potassium para-amino benzoate). In 10% of cases, there is a recurrence of Peyronie's disease, in any case despite many believed the disease impervious to medical therapy, since 1997 has brought the percentage of patients requiring surgery for deformity of the penis by about 45% to 10% or more.