Apomorphine is a dopamine agonist used to treat occasional episodes of immobility associated with symptoms of Parkinson's disease. This is the first drug that can be injected when the muscles become rigid and stiff and that person can no longer pick up a seat or not and can perform daily activities. Apomorphine treatment given at need may make possible the reduction of dopamine agonist’s doses. This leads to lower adverse effects such as involuntary movements and seizures. There may be some cases where treatment is going for the steady dose of levodopa and dopamine agonists and some doses of apomorphine, when needed, rather than undergo a treatment where the oral drug doses are adjusted according to the emergencies occurred.

Apomorphine must be administered with anti-emetic drugs to prevent nausea and vomiting appearance. Recent studies show that treatment with high doses of antioxidant coenzyme Q10 may slow progression of Parkinson's disease, but should be taken in the early stages of disease. Further studies are needed to determine how safe is the treatment and its effectiveness.

Ongoing treatment may be a number of drugs used to treat Parkinson's disease in its various stages.
*Generally, the initial treatment of Parkinson's disease begins with:
-Dopamine agonists (bromocriptine, pergolide, pramipexole, ropinirole);
-Levodopa and carbidopa;
-Peripheral inhibitor of catechol-0-methyltransferase (COMT) inhibitors, entacapone, tolcapone;
-Anticholinergic agents (benztropina, trihexifenidil)
-Selegiline - inhibitor of monoamine oxidase type B;
-Amantadine.



*Note!
All drugs used to treat Parkinson's can have unpleasant side effects. Medical treatment is ideal to control symptoms and side effects are well tolerated by patients. Doctors generally will try one drug at a time and will recommend a low dose to minimize adverse effects.
It is good to know that:
- Levodopa and other medicines may be more effective if taken before meals;
- Sudden stopping medication can worsen symptoms and can be dangerous.
A number of complications can occur after a long treatment for Parkinson's disease, which may include:
- Unexpected changes in patient response to medication;
- Twitching or convulsions.



Problems can occur as a result of the disease itself, such as:
- Unable to move
- Decreased muscle tone.
Changing the dosage or using a different combination of drugs can be helpful in such situations. Necessary medicines treating this disorder are prescribed by the practitioner and the patient must be well informed about how they have to take them. It is very important to strictly observe the patient for a doctor's recommendations as a result of better therapy.

*Surgery
Surgery may be considered when medication can no longer control symptoms of Parkinson's disease or when side effects are quite severe and affect daily activities of the patient.